Although I can't think of any notable examples off the top of my head, the private detective meets Lovecraftian horrors novel is pretty much a staple of genre-mashing pulp fiction at this point. But given the ichorous saturation of The Elder Gods in our midst, how is it the MI6 has never fought Nylarlathotep and Azathoth? And how what gadgets could Q possibly muster up to help James Bond stare into the madness-inducing tentacled maw of the Great Cthulhu?
Charles' Stross' novel The Jennifer Morgue isn't quite that cool: it would require permission from the notoriously cagey Fleming Estate (Christ, they thought Kingsley Amis wasn't good enough to write a James Bond novel!). BUt Stross has done the best he can to write a series of potboilers about British Intelligence's ongoing confrontation with Lord Cthulhu.
Stross' description of his novel:
Which raises the question: exactly what genre of fiction wouldn't benefit from the addition of the Cthulhu Mythos? Cthulhu westerns! Cthulhu biographies! And I'd particularly like to see a reinterpretation of Tolkein incorporating Cthulhu's influence on Middle Earth.
Author Interview Week: Charles Stross [By The Way] (via Boing Boing)
