
A band called The Guitar Zeros deciphered the Guitar Hero controller's data commands and connected them to the limitless Max/MSP software to create music more complex than what would seem to be possible with a five-button fretboard.
The video is not embeddable, and you have to sit through a Verizon ad before you can see and hear the band in action, but it's worth the effort:
Update: The Guitar Zeros have a video on YouTube from one of their live shows... the crowd goes wild:
https://www.youtube.com/watch?v=d9e56cxCduo
